Exploding from their own hit show, the perfectly mindless Pinky and the brilliant Brain continue pursuing Brain's daily obsession to take over the world. But one person stands in their way: Elmyra, the cutesy-wutesy little girl who loves animals so much it hurts!

It's one outrageous ordeal after another when the genetically enhanced mice lose their previous home at ACME Labs and are forced to move in with Elmyra, as her pets. Pinky and The Brain's madcap attempts to avoid Elmyra in 13 laugh-out-loud episodes that parody everything from classic literature to popular movies aired on the WB Kids network during the 1998-1999 season.